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    For the manifestation of its effects Irbesartan does not require metabolic activation. Irbesartan lowers blood pressure with minimal change in heart rate. When taken in doses up to 300 mg 1 time per day reduction in blood pressure is dose-dependent, but with further increase in the dose of the hypotensive effect of irbesartan growth is negligible.

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    Respectively compared with placebo. The antihypertensive effect is maintained in long-term treatment. After order Avapro Generic Online of treatment blood pressure gradually returns to the initial value, withdrawal symptoms were observed. Pharmacokinetics Once inside well absorbed from the gastrointestinal tract. Cmax of irbesartan in order Avapro Generic Online achieved through 1. Irbesartan has linear pharmacokinetics and dose proportional in the dose range from 10 to 600 mg; at doses greater than 600 mg 2-fold higher than the maximum recommended dose becomes nonlinear kinetics of irbesartan decrease absorption.

    Binding to cellular components of blood is insignificant.

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    Vd — 53 — 93 liters. When taken daily 1 times a day Css achieved within 3 days.

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    Irbesartan biotransformed in the liver by oxidation and order Avapro Generic Online with glucuronic acid. Pharmacokinetics in special clinical situations The somewhat higher plasma concentrations of irbesartan were observed in women compared to men. Correction doses of irbesartan in women is required. Correction doses of irbesartan in elderly patients is not required.

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    • In the placebo — controlled studies 1965 patients received irbesartan were observed following adverse reactions.
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    The order Avapro Generic Online and maintenance dose is 150 mg 1 time per day regardless of the order Avapro Generic Online. However, buy Finasteride some cases, especially in patients who are on hemodialysis or in patients over the age of 75 years, the starting dose should be 75 mg may use Avaproya in tablets of 75 mg. In patients with hypertension and type 2 diabetes, treatment should be started at a dose of 150 mg 1 time per day and gradually increase to 300 mg — dose, which is the preferred maintenance dose for the treatment of nephropathy.

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